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A new reductive procedure for the preparation of vicinal diamines and monoamines

✍ Scribed by Sang-Hun Jung; Harold Kohn


Publisher
Elsevier Science
Year
1984
Tongue
French
Weight
216 KB
Volume
25
Category
Article
ISSN
0040-4039

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✦ Synopsis


sumnary: Selective reductive procedures for the preparation of vicinal diamines and rrpncmines fran alkyl bromxyanamides are described.

The frequent occurrence of the vicinal diamine functionality (1, in important naturally occurring compounds and medicinal agents renders this group a worthy synthetic target.

Currently, few general methods exist for the preparation of vicinal diamines.3 Recently we reported4 a novel diamination procedure which utilized unactivated olefins (11, cyanamide (11, and N-br~succinimide (Scheme 1). The overall reaction was stereospecific and permitted


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