A New Reaction Pathway in the Enantioselective Hydrogenation of Activated Ketones on Cinchona-Modified Platinum
✍ Scribed by M von Arx; T Mallat; A Baiker
- Book ID
- 112256486
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 93 KB
- Volume
- 202
- Category
- Article
- ISSN
- 0021-9517
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📜 SIMILAR VOLUMES
The enantioselective hydrogenations of ethyl pyruvate (EP), methyl benzoylformate (MBF), ketopantolactone (KPL) and pyruvaldehyde dimethylacetal (PADA) were studied on Pt-alumina catalyst modified by a new modifier namely ␣-isoquinine (␣-IQ) with rigid conformation and for comparison by quinine (Q)
Various derivatives of (R)-1-(1-naphthyl)ethylamine have been synthesized and tested as chiral modifiers of Pt/alumina in the enantioselective hydrogenation of ketopantolactone. The best modifiers (ee up to 79%) possess an ester function in the a-position to the amino group. The modifiers performed