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A New Rational Hypothesis for the Pharmacophore of the Active Metabolite of Leflunomide, a Potent Immunosuppressive Drug

✍ Scribed by Bertolini, Giorgio; Aquino, Mario; Biffi, Mauro; d'Atri, Gaetano; Di Pierro, Francesco; Ferrario, Francesco; Mascagni, Paolo; Somenzi, Flavio; Zaliani, Andrea; Leoni, Flavio


Book ID
125534804
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
149 KB
Volume
40
Category
Article
ISSN
0022-2623

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β′-Hydroxy-α,β-unsaturated ketones: A ne
✍ Leticia G. León; Rubén M. Carballo; María C. Vega-Hernández; Pedro O. Miranda; V 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 487 KB 👁 1 views

## Abstract Novel antiproliferative β′‐acyloxy‐__α,β__‐unsaturated ketones were obtained by means of an iron(III)‐catalyzed multicomponent domino process (ABB′ 3CR). The most active derivatives displayed GI~50~ values in the range of 0.5–3.9__μ__M against a panel of representative human solid tumor