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β′-Hydroxy-α,β-Unsaturated Ketones: A New Pharmacophore for the Design of Anticancer Drugs.

✍ Scribed by Jose M. Padron; Pedro O. Miranda; Juan I. Padron; Victor S. Martin


Publisher
John Wiley and Sons
Year
2006
Weight
13 KB
Volume
37
Category
Article
ISSN
0931-7597

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β′-Hydroxy-α,β-unsaturated ketones: A ne
✍ Leticia G. León; Rubén M. Carballo; María C. Vega-Hernández; Pedro O. Miranda; V 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 487 KB

## Abstract Novel antiproliferative β′‐acyloxy‐__α,β__‐unsaturated ketones were obtained by means of an iron(III)‐catalyzed multicomponent domino process (ABB′ 3CR). The most active derivatives displayed GI~50~ values in the range of 0.5–3.9__μ__M against a panel of representative human solid tumor