β′-Hydroxy-α,β-unsaturated ketones: A ne
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Leticia G. León; Rubén M. Carballo; María C. Vega-Hernández; Pedro O. Miranda; V
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Article
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2008
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John Wiley and Sons
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English
⚖ 487 KB
## Abstract Novel antiproliferative β′‐acyloxy‐__α,β__‐unsaturated ketones were obtained by means of an iron(III)‐catalyzed multicomponent domino process (ABB′ 3CR). The most active derivatives displayed GI~50~ values in the range of 0.5–3.9__μ__M against a panel of representative human solid tumor