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A new polymorphic site in the G6PD gene

✍ Scribed by Ernest Beutler; Beryl Westwood; Brian Sipe

Publisher
Springer
Year
1992
Tongue
English
Weight
197 KB
Volume
89
Category
Article
ISSN
0340-6717

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✦ Synopsis

A polymorphic restriction site has been found in intron 11 of the gene for glucose-6-phosphate dehydrogenase (G6PD). This site is produced by a T----C substitution 13 bp upstream of exon 12, producing an NlaIII restriction site. In various populations there was a strong association between a T at nt 1311 of the G6PD cDNA and the presence of the NlaIII restriction site. Among African Americans, however, the presence of a C at nt 1311 was sometimes associated with the presence of a polymorphic NlaIII site.

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