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G-6PD “ankara”. A new G-6PD variant with deficiency found in a Turkish family

✍ Scribed by Axel Kahn; M. L. North; J. Messer; P. Boivin

Publisher
Springer
Year
1975
Tongue
English
Weight
317 KB
Volume
27
Category
Article
ISSN
0340-6717

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✦ Synopsis

A new G-6PD varient with enzyme deficiency is described in a 7-month-old Turkish boy without any hemolytic manifestation, except neonatal hyperbilirubinemia. The main characteristics of this variant were the following: Severe enzyme deficiency in erythrocytes (8% of normal), fast starch-gel-electrophoretic mobility (110% of normal), increased Ki NADPH with respect to NADP+, slightly biphasic pH curve, enzyme instability, in vivo and in vitro, decreased molecular specific activity (58% of normal).

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G6PD deficiency with Gd(-)A like variant
G6PD deficiency with Gd(-)A like variant in a Chinese family from Cambodia
✍ J. L. Viallard; D. Cottreau; A. Kahn; B. Dastugue 📂 Article 📅 1979 🏛 Springer 🌐 English ⚖ 132 KB

A low rate value of G6PD was found in red blood cells from a Cambodian boy. Enzyme mapping was performed according to the WHO standard methods. G6PD presented all the characteristics of the A(-) variant encountered in the Negroes and behaved distinct from fast migrating enzymes described in China. N