A new nonionic macrocyclic gadolinium(III) chelate as a potential magnetic-resonance-imaging contrast agent
β Scribed by Michiko B. Inoue; Paul Oram; Motomichi Inoue; Quintus Fernando; Andrew L. Alexander; Evan C. Unger
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 447 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0730-725X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract We have developed a new class of magnetic resonance imaging contrast agents with large proton relaxation enhancements and high molecular relaxivities. The reagents are built from the polyamidoamine form of Starbursβ’ dendrimers in which free amines have been conjugated to the chelator 2β
The introduction of a lipophilic moiety into the gadolinium chelate Gd-DTPA (dimeglumine gadopentetate, Magnevist) yielded Gd-EOB-DTPA (short form), which has potential as a magnetic resonance contrast agent for liver mass screening. The pharmacokinetics of Gd-EOB-DTPA in rats is nonlinear because a