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A new model system for studying the phosphatidylinositol cycle

✍ Scribed by Marie E. Monaco; Marc E. Lippman

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
643 KB
Volume
112
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

An early manifestation of the response of WRK‐1 rat mammary tumor cells to vasopressin is an increase in incorporation of (^32^P)P~i~ into phospholipids. Incorporation into all classes of phospholipids is stimulated; however, incorporation into phosphatidylinositol (PI) is increased to the greatest degree (3‐ to 10‐fold as compared with 1.3‐ to 2‐fold for the other phosholipids). Furthermore, increased incorporation into PI is accompanied by an increased rate of PI turnover; turnover rates of the other phospholipids are unaffected by vasopressin.

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