A New Method for the Synthesis of 2′- O -Benzyladenosine Using Mitsunobu Reaction
✍ Scribed by Kozai, Shigetada; Fuzikawa, Tomoyo; Harumoto, Keisuke; Maruyama, Tokumi
- Book ID
- 126731943
- Publisher
- Taylor and Francis Group
- Year
- 2003
- Tongue
- English
- Weight
- 334 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0732-8311
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## Abstract The __Mitsunobu__ reaction is an important tool in carbocyclic nucleoside chemistry for the direct coupling of alcohols with heterocyclic bases under mild conditions. Chemical evidences for an unusual competitive __O__^2^‐ __vs. N__^1^‐alkylation of 3‐substituted pyrimidines is presente
Compounds l-7 were synthesized from maleimicfe and the corresponding alcohols using a novel application of the Mitsunobu reaction. This procedure allows the direct formation of a variety of bifunctional linker compounds. Bifunctional linkers, with a maleimido group attached to one end and a connecta