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A new method for analysis of AZT-triphosphate and nucleotide-triphosphates

✍ Scribed by Jeroen J.A van Kampen; Pieter L.A Fraaij; Vishal Hira; Annemarie M.C van Rossum; Nico G Hartwig; Ronald de Groot; Theo M Luider


Book ID
116287912
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
313 KB
Volume
315
Category
Article
ISSN
0006-291X

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Synthesis of a non-hydrolyzable AZT-trip
✍ Thierry Brossette; Alain Valleix; Laure Goujon; Christophe CreΒ΄minon; Jacques Gr πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 261 KB

An enzymatically stable analogue of AZT-triphosphate is prepared in 7 steps starting from thymidine. The thymine moiety is thnctionalized at N 3 to allow the further cross-linking to a carrier protein for subsequent immunization of rabbits in order to raise specific antibodies directed against AZT-T