✦ LIBER ✦
Synthesis of a non-hydrolyzable AZT-triphosphate analogue designed for the production of anti-AZT-TP antibodies
✍ Scribed by Thierry Brossette; Alain Valleix; Laure Goujon; Christophe Cre´minon; Jacques Grassi; Charles Mioskowski; Luc Lebeau
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 261 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
An enzymatically stable analogue of AZT-triphosphate is prepared in 7 steps starting from thymidine. The thymine moiety is thnctionalized at N 3 to allow the further cross-linking to a carrier protein for subsequent immunization of rabbits in order to raise specific antibodies directed against AZT-TP.