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A new metabolite of butylated hydroxyanisole in man

✍ Scribed by Ragab El-Rashidy; Sarfaraz Niazi

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
317 KB
Volume
4
Category
Article
ISSN
0142-2782

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✦ Synopsis

Abstract

Butylated hydroxyanisole (I) is one of the most commonly used food antioxidants. Its use has been suggested to inhibit a variety of carcinogenic responses. The present study on the disposition kinetics of (I) in man indicates that contrary to previous reports, (I) undergoes significant O‐demethylation in the body yielding a tert‐butyl hydroquinone. It is suggested that this metabolic conversion may be responsible for some of the in vivo activities of (I) against chemical carcinogens.

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✍ Hsueh-Fu Lu; Hsi-Chin Wu; Te-Chun Hsia; Wen-Chi Chen; Chi-Fu Hung; Jing-Gung Chu πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 143 KB

## Abstract In this study, butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) were used to determine the inhibition of arylamine __N__‐acetyltransferase (NAT) activity and DNA adduct formation in human bladder tumour cell line T‐24. The activity of NAT was measured by high‐performanc