The BB rat spontaneously develops insulin-dependent diabetes mellitus of autoimmune aetiology. From breeding studies, one of the genes necessary for the development of diabetes in these animals is linked to RT1, the rat's major histocompatibility complex. To study further the RT1 linked diabetogenic
A new major histocompatibility complex class I b gene expressed in the mouse blastocyst and placenta
โ Scribed by Susan L. Sipes; Maxine V. Medaglia; Deborah L. Stabley; Craig S. DeBruyn; Mark S. Alden; Vicki Catenacci; C. P. Landel
- Publisher
- Springer-Verlag
- Year
- 1996
- Tongue
- English
- Weight
- 458 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0093-7711
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The expression of the major histocompatibility complex Class I antigens (Class I) was investigated in the nervous system of twitcher (C57BL/6J-twi), a murine model of Krabbe disease in humans. Class I mRNA expression was low in wild type and in twitcher mice prior to the onset of demyelination. Howe
Mechanisms of major histocompatibility complex (MHC) class I gene regulation in cells of the CNS have been studied in vitro. Astrocytes in primary cultures, but neither oligodendrocytes nor neurons, constitutively expressed cell surface MHC class I molecules. Interferon-gamma (IFN-.I) treatment led