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A new inhalation exposure system for the determination of inhaled doses in laboratory rats

โœ Scribed by Carroll A. Snyder; Alan B. Bowers

Publisher
Springer-Verlag
Year
1987
Tongue
English
Weight
301 KB
Volume
61
Category
Article
ISSN
0340-5761

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โœฆ Synopsis

A new inhalation exposure system has been developed which allows the determination of inhaled doses of vapors and gases by laboratory rats. The system consists of saran bags connected to head-only exposure cylinders via one-way valves. One bag serves as the source of contaminant and another receives expired air. The exposure cylinders also serve as whole body plethysmographs. Up to three rats can be exposed concurrently to the same concentration of test material. The construction of the system and its use for inhalation exposures to a direct-acting radiolabeled carcinogen are described.

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