A repeated dose study of the toxicity of inhaled 2-chlorobenzylidene malononitrile (CS) aerosol in three species of laboratory animal
✍ Scribed by T. C. Marrs; H. F. Colgrave; N. L. Cross; M. F. Gazzard; R. F. R. Brown
- Publisher
- Springer-Verlag
- Year
- 1983
- Tongue
- English
- Weight
- 782 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0340-5761
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✦ Synopsis
The repeated dose inhalation toxicity of 2-chlorobenzylidene maloninitrile (CS) was investigated in male mice, rats, and guinea-pigs. Exposure was 1 h X day-1 for 120 days surviving animals being killed approximately 1 year after the start of exposure. Excess mortality was noted in the high dose groups of all three species but at exposure concentrations below 30 micrograms X 1(-1) mortality varied little between the control and test groups. Death during the experiment was related to concentration of exposure rather than total dose (Ct). No case of a dose-response relationship between tumours in a particular site, and total dose of CS was noted.