A New Group of Antischistosomal Compounds
โ Scribed by Dr. Paul Schmidt; Dr. Max Wilhelm
- Publisher
- John Wiley and Sons
- Year
- 1966
- Tongue
- English
- Weight
- 598 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0044-8249
No coin nor oath required. For personal study only.
โฆ Synopsis
A number of c o r n p o ~n ~
containing the ~"ni~ro-Z-~hiuzolyl group are suitable for the freatmefit of sc~~st~sorniasis; ~~~5-ni~~o-Z-th~azo~yi)-Z-imidazoIid~~one is pariicuiarly eflective.
The compounds are taken up selecfively by the sclristosornes causing the disease and by their eggs, and destroy bath. -A review of earlier attempts to control this tropical disease is also presented in thrs co?nrnun~catian.
๐ SIMILAR VOLUMES
N-(9H-Xanthen-9-yl)succinimide (1) is prepared by the reaction of xanthene with N-bromosuccinimide. Hydrolysis of 1 with 5% NaOH yields 3-[(9H-xanthen-9-yl)inocarbonyl]propionic acid (3a). The corresponding methyl ester 3c is obtained from 3a by the action of diazomethane. The butanol derivative 4a