A New Entry to Bis-Tröger’s Bases
✍ Scribed by Thierry Mas; Carmen Pardo; Francisca Salort; José Elguero; M. Rosario Torres
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 179 KB
- Volume
- 2004
- Category
- Article
- ISSN
- 1434-193X
No coin nor oath required. For personal study only.
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## Abstract Four novel molecular tweezers, **6**–**9**, have been synthesized having, for the first time, three fused __Tröger__'s bases. The compounds differ in the relative configuration of the three fused methylene bridges and have been unambiguously characterized by NMR.
Under acidic conditions the enantiomers of Tröger's base 1 (2,8-dimethyl-6 H,12 H-5,11-methanodibenzo[b,f][1,5]diazozine) are subject to enantiomerization. During enantioselective dynamic electrokinetic chromatography using 10 mM hydroxypropyl-beta-cyclodextrin as the chiral mobile phase additive in