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A New Drug Design Targeting the Adenosinergic System for Huntington's Disease

✍ Scribed by Huang, Nai-Kuei; Lin, Jung-Hsin; Lin, Jiun-Tsai; Lin, Chia-I; Liu, Eric Minwei; Lin, Chun-Jung; Chen, Wan-Ping; Shen, Yuh-Chiang; Chen, Hui-Mei; Chen, Jhih-Bin; Lai, Hsing-Lin; Yang, Chieh-Wen; Chiang, Ming-Chang; Wu, Yu-Shuo; Chang, Chen; Chen, Jiang-Fan; Fang, Jim-Min; Lin, Yun-Lian; Chern, Yijuang; Manzoni, Olivier Jacques

Book ID: 120454446
Publisher: Public Library of Science
Year: 2011
Tongue: English
Weight: 749 KB
Volume: 6
Category: Article
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0020934

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## Abstract Activating the ERK pathway (extracellular signal‐regulated kinase pathway) has proven beneficial in several models of Huntington's disease (HD), and drugs that are protective in HD models have recently been found to activate ERK. Thus, the ERK cascade may be a potential target for thera