𝔖 Bobbio Scriptorium
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Particle shape: A new design parameter for passive targeting in splenotropic drug delivery

✍ Scribed by Padma V. Devarajan; Anil B. Jindal; Rajesh R. Patil; Fernaz Mulla; Rajiv V. Gaikwad; Abdul Samad

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
381 KB
Volume
99
Category
Article
ISSN
0022-3549

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✦ Synopsis

The role of particle size and surface modification on biodistribution of nanocarriers is widely reported. We report for the first time the role of nanoparticle shape on biodistribution. Our study demonstrates that irregular shaped polymer lipid nanoparticles (LIPOMER) evade kupffer cells and localize in the spleen. We also demonstrate the macrophage-evading characteristic of the irregular-shaped LIPOMER. Our results suggest particle shape as an important tool for passive targeting of nanocarriers in splenotropic drug delivery.

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