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A New Cytotoxic and Tubulin-Interactive Milnamide Derivative from a Marine Sponge Cymbastela sp.

✍ Scribed by Chevallier, Camille; Richardson, Adam D.; Edler, Michael C.; Hamel, Ernest; Harper, Mary Kay; Ireland, Chris M.


Book ID
126405576
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
42 KB
Volume
5
Category
Article
ISSN
1523-7060

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Jaspines A and B: two new cytotoxic sphi
✍ VΓ©ronique Ledroit; CΓ©cile Debitus; Catherine Lavaud; Georges Massiot πŸ“‚ Article πŸ“… 2003 πŸ› Elsevier Science 🌐 French βš– 125 KB

The ethanolic extract of the sponge Jaspis sp. collected in Vanuatu showed cytotoxicity against KB tumour cells (IC 95 =10 mg/ml). A bioassay-guided fractionation led to the isolation of two new cytotoxic sphingosine derivatives, jaspine A and jaspine B. Structures were elucidated by spectroscopic m