## Abstract Data presently available suggest that polycythemia vera is an acquired clonal disorder of the pluripotent stem cell resulting in expansion of committed stem cell pools, most prominently in the erythroid line. In vitro and in vivo studies suggest that erythropoiesis in polycythemia vera
A new cytogenetic aspect of polycythemia vera
β Scribed by F. Shabtai; S. Weiss; E. Lijn; U. Lewinski; M. Djaldetti; I. Halbrecht
- Publisher
- Springer
- Year
- 1978
- Tongue
- English
- Weight
- 330 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0340-6717
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β¦ Synopsis
The cytogenetic findings in a group of 15 polycythemic patients are reported. G and C banding techniques were used on bone marrow and peripheral blood preparations. Major chromosomal aberrations were found in four out of the 15 patients, an incidence similar to that found in other studies on polymorphism. The most interesting finding concerned the chromosomal polymorphism of the pair 19. A possible relation to the etiology of the disease is discussed.
π SIMILAR VOLUMES
Among the chronic myeloproliferative disorders, polycythemia vera and essential thrombocythemia are unique because of their association with thrombohemorrhagic manifestations and their relatively indolent clinical course. Patients with essential thrombocythemia may not have a significant shortening