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A new convenient synthesis of 2,4-disubstituted-1,2,4-triazolo[1,5-a] quinazolin-5(4H)-ones

✍ Scribed by Ahmad S. Shawali; Hamdi M. Hassaneen; Nabil Kh. Shurrab

Publisher
Journal of Heterocyclic Chemistry
Year
2008
Tongue
English
Weight
215 KB
Volume
45
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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A novel series of 2,4‐disubstituted‐1,2,4‐triazolo[1,5‐a]quinazolin‐5(4__H__)‐ones were prepared by Dimroth rearrangement of their respective isomers namely 1,4‐disubstituted‐[1,2,4]triazolo[4,3‐a]‐quinazolin‐5(4__H__)‐ones. The latter were prepared via new synthetic strategy based on 1,5‐elecrocyclization of the respective N‐(4‐oxo‐3‐phenylquinazolin‐2‐yl)nitrilimines.

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