A new concise synthesis of nectrisine and its facile conversion to phosphonoazasugars

✍ Scribed by Michaël Bosco; Philippe Bisseret; Claire Bouix-Peter; Jacques Eustache

• Book ID: 104231732
• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 254 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)01684-7

✦ Synopsis

The synthesis of new sugar-derived phosphonic acids from protected nectrisine is described. The key step is a highly stereoselective addition of a phosphonate anion to a sugar-derived dihydropyrrole to provide a versatile synthetic intermediate which can be functionalised in multiple ways.