𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A new class of potent thrombin inhibitors that incorporates a scissile pseudopeptide bond

✍ Scribed by John DiMaio; Feng Ni; Bernard Gibbs; Yasuo Konishi


Book ID
115924757
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
939 KB
Volume
282
Category
Article
ISSN
0014-5793

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


(N-acyl-N-alkyl)glycyl borolysine analog
✍ Robert A. Galemmo Jr.; John M. Fevig; David J. Carini; Joseph Cacciola; Brian L. πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 English βš– 372 KB

In this report the structure-activity relationships of a series of novel (N-acyl-N-alkyl)glycyl borolysine thrombin inhibitors are described. This work culminates in the discovery of (N-3phenylpropanoyl-N-phenethyl)glycyl borolysine (12j), a potent, orally active inhibitor with a binding conformatio