(N-acyl-N-alkyl)glycyl borolysine analog
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Robert A. Galemmo Jr.; John M. Fevig; David J. Carini; Joseph Cacciola; Brian L.
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Article
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1996
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Elsevier Science
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English
β 372 KB
In this report the structure-activity relationships of a series of novel (N-acyl-N-alkyl)glycyl borolysine thrombin inhibitors are described. This work culminates in the discovery of (N-3phenylpropanoyl-N-phenethyl)glycyl borolysine (12j), a potent, orally active inhibitor with a binding conformatio