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A new class of nitrosoureas. 4. Synthesis and antitumor activity of disaccharide derivatives of 3,3-disubstituted 1-(2-chloroethyl)-1-nitrosoureas

✍ Scribed by Tsujihara, Kenji; Ozeki, Masakatsu; Morikawa, Tamio; Kawamori, Masatoshi; Akaike, Yukio; Arai, Yoshihisa


Book ID
126999418
Publisher
American Chemical Society
Year
1982
Tongue
English
Weight
747 KB
Volume
25
Category
Article
ISSN
0022-2623

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Physiologic disposition of 1-(2-chloroet
✍ Robert W. Sponzo; Vincent T. Devita; Vincent T. Oliverio πŸ“‚ Article πŸ“… 1973 πŸ› John Wiley and Sons 🌐 English βš– 466 KB πŸ‘ 2 views

The physiologic disposition of radioactive-labelled CCNU and MeCCNU was studied in patients receiving these drugs as part of their early clinical trial. CCNU was given orally in doses of 30-100 mg/m2 a n d MeCCNU in doses of 120-290 mg/m?. With both drugs, significant plasma levels of radioactivity