A new characteristic karyotypic anomaly in lymphoproliferative disorders

✍ Scribed by H. Van Den Berghe; C. Parloir; G. David; J. L. Michaux; G. Sokal

• Publisher: John Wiley and Sons
• Year: 1979
• Tongue: English
• Weight: 805 KB
• Volume: 44
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(197907)44:1<188::aid-cncr2820440131>3.0.co;2-f

✦ Synopsis

A new characteristic chromosome anomaly t(l1; 14)(q14;q32?) in lymphoproliferative disorders (LPD) is described in 4 cases. The extra material was found on a # 14 chromosome (14q+) and belonged to the long arm of one # 11 chromosome in 3 cases and to the long arm of a #14 in the other case. These cases confirm that the distal end of chromosome 14q may function as a "receptor site," according to the hypothesis of Kaiser-McCaw et a2." and also tend to indicate that chromosome #14 may not be unique in showing so-called "donor" and "receptor sites," and that other chromosomes, in casu chromosome #11, may behave similarly.

Cancer 44:188-195, 1979. YTOGENETIC STUDIES I N malignant C lymphoma have been performed ever since reliable analysis of human chromosomes became available. Besides some individual cases, a number of papers with series of malignant lymphomas studied before banding techniques were introduced have been published-Sandberg et aLZ5 Baker and Atkin,' Sasaki et a1.,26 Miles et aZ.," Millard,lS and Spiers and Baikie.

28 Even though the nature of the tissues that were investigated and the methodologies used varied considerably, these studies generally agreed on the following points: 1) many and possibly the majority of lymphomas show karyotypic anomalies, and these are more prevalent in less well differentiated tumors, 2) numerical anomalies are frequent, and the modal chrpmosome numbers of the abnormal cells are in the diploid or hyperdiploid range with some cases being near tetraploid (hypodiploidy is rare), and 3) structural chromosome abnormalities are frequently observed, but no characteristic