𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Complex karyotypic anomalies in a bizarre leiomyoma of the uterus

✍ Scribed by Dr. Mef Nilbert; Sverre Heim; Nils Mandahl; Ulla-Maria Flodérus; Helena Willén; Bo Baldetorp; Felix Mitelman

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
331 KB
Volume
1
Category
Article
ISSN
1045-2257

No coin nor oath required. For personal study only.

✦ Synopsis

Cytogenetic investigation of short-term cultures from a bizarre leiomyoma of the uterus, a tumor type not hitherto karyotypically characterized, revealed two abnormal clones with multiple complex rearrangements. Three-fourths of the aberrant cells were hypodiploid with the composite karyotype 38-44,)<)<.-6,-7,-10,-I I,+20,-22,r( I),der(2) (:2p23-+cen+2q 13:: lq2 I+ I qter),der(2)t(2;9)(p21 ;q I3),t(s;?)(q35;!),t(5;?),(q35;?),+der(5)t(5; I5)(q I I ;q I5), der(8)t(8; I l)(q24;q I 3),t( I5;?)(p I 2;?),der( I6)t( 12; I6)(q I 3;p I 3),+r,+mar. The remaining abnormal mitoses were hypotetraploid, with chromosome numbers ranging from 74 to 86. These massively rearranged cells showed the same markers that were found in the hypodiploid clone, but in duplicate, indicating that this clone had arisen through polyploidization of hypodiploid cells. Flow cytometry revealed a DNA index of I .03.

📜 SIMILAR VOLUMES

Complex karyotypic abnormalities in a pr
Complex karyotypic abnormalities in a primary carcinoma of the fallopian tube
✍ Dr. Georgia Bardi; Tatjana Sukhikh; Nikos Pandis; Berit Hølund; Sverre Heim 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 280 KB

## Short -term cultures from a primary carcinoma of the Fallopian tube, a tumor type not characterized before by chromosome banding, were examined cytogenetically. Complex chromosome aberrations were found in all mitoses, yielding the karyotype 41,XX,del(I)(p34),de1(2)(q31),i(8)(qI0),-9,+dic(9;I9)

Gains, losses and complex karyotypes in
Gains, losses and complex karyotypes in myeloid disorders: a light at the end of the tunnel
✍ Sara Alvarez; Juan C. Cigudosa 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 164 KB

Complex karyotypes are seen in approximately 15% of de novo MDS/AML and in up to 50% of therapy-related MDS/AML. These patients represent a therapeutic challenge for which no current treatment approach is satisfactory. Therefore, a large number of genetic studies using cytogenetic molecular techniqu

Characterization of the expression and s
Characterization of the expression and steroid hormone control of sialomucin complex in the rat uterus: Implications for uterine receptivity
✍ Richard R. McNeer; Coralie A. Carothers Carraway; Nevis L. Fregien; Kermit L. Ca 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 299 KB 👁 2 views

The sialomucin complex (SMC), originally isolated as a heterodimeric glycoprotein complex from membranes of ascites sublines of a highly metastatic mammary adenocarcinoma, consists of a high M r mucin subunit (ASGP-1, ascites sialoglycoprotein) and a transmembrane subunit (ASGP-2) with two epidermal

Ploidy and karyotype complexity are powe
Ploidy and karyotype complexity are powerful prognostic indicators in the Ewing's sarcoma family of tumors: A study by the United Kingdom Cancer Cytogenetics and the Children's Cancer and Leukaemia Group
✍ Paul Roberts; Susan A. Burchill; Samantha Brownhill; Catherine J. Cullinane; Col 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 386 KB 👁 1 views

## Abstract Ewing's sarcoma family tumors (ESFT) are characterized by the presence of __EWSR1‐ETS__ fusion genes. Secondary chromosome changes are frequently described, although their clinical significance is not clear. In this study, we have collected and reviewed abnormal karyotypes from 88 patie