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A new case of malonyl coenzyme A decarboxylase deficiency presenting with cardiomyopathy

✍ Scribed by S. Yano; L. Sweetman; D. R. Thorburn; S. Mofidi; J. C. Williams


Publisher
Springer
Year
1997
Tongue
English
Weight
66 KB
Volume
156
Category
Article
ISSN
0340-6997

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A new series of thiazole-substituted 1,1,1,3,3,3-hexafluoro-2-propanols were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Key analogs caused dose-dependent decreases in food intake and body weight in obese mice. Acute treatment with these compounds also led to a drop in elev