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A new approach to the synthesis of 4,5-dioxoaporphine alkaloids from preformed biaryl bond precursors

✍ Scribed by Rafael Suau; Juan Manuel López-Romero; Rodrigo Rico; Francisco J. Alonso; Carolina Lobo


Book ID
107857936
Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
793 KB
Volume
52
Category
Article
ISSN
0040-4020

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A versatile approach to the synthesis of
✍ Rafael Suau; Juan Manuel López-Romero; Rodrigo Rico 📂 Article 📅 1996 🏛 Elsevier Science 🌐 French ⚖ 230 KB

Cyelization of biaD:lacetamides to their phenanthrene derivatives is promoted by oxalyl ehloride/stannyl chloride. The reaction proceeds with a second cyclization in which the oxalyl fragment acts as an t~-dicarlx~vI transfer agent to give 4,5-dioxoaporphine alkaloids in a single step. This double c