A new approach to the solid-phase Suzuki coupling reaction
✍ Scribed by Serge R. Piettre; Sylvie Baltzer
- Book ID
- 104256436
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 255 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Treatment of polymer-bound aryl halides with pinacol ester of diboron under palladium (0) catalysis gave the corresponding polymer-bound boronates. The Suzuki coupling reaction was then carried out using a variety of aryl halides. Cleavage from the solid support delivered the expected products in usually good yields and high purity.
📜 SIMILAR VOLUMES
## Abstract For Abstract see ChemInform Abstract in Full Text.
The Suzuki cross-coupling reaction was found effective for rapid access to a series of 3,4diarylisoxazoles of pharmacological interest. The efficiency of this approach was demonstrated by the synthesis of the highly potent COX-2-selective inhibitor, 4-(5-methyl-3-phenyl-4-isoxazolyl)benzenesulfonami
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v