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Convenient Approach to 3,4-Diarylisoxazoles Based on the Suzuki Cross-Coupling Reaction.

✍ Scribed by J. S. Dileep Kumar; ManKit M. Ho; Jennifer M. Leung; Tatsushi Toyokuni

Book ID
101939384
Publisher
John Wiley and Sons
Year
2003
Weight
121 KB
Volume
34
Category
Article
ISSN
0931-7597

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Convenient Approach to 3,4-Diarylisoxazo
Convenient Approach to 3,4-Diarylisoxazoles Based on the Suzuki Cross-Coupling Reaction
✍ J. S. Dileep Kumar; ManKit M. Ho; Jennifer M. Leung; Tatsushi Toyokuni 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 89 KB

The Suzuki cross-coupling reaction was found effective for rapid access to a series of 3,4diarylisoxazoles of pharmacological interest. The efficiency of this approach was demonstrated by the synthesis of the highly potent COX-2-selective inhibitor, 4-(5-methyl-3-phenyl-4-isoxazolyl)benzenesulfonami