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A New and Facile Synthesis of Quinazoline-2,4(1 H ,3 H )-diones

โœ Scribed by Jiarong, Li; Xian, Chen; Daxin, Shi; Shuling, Ma; Qing, Li; Qi, Zhang; Jianhong, Tang


Book ID
120202154
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
171 KB
Volume
11
Category
Article
ISSN
1523-7060

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A new synthesis of a series of 3-amino-1H-quinazoline-2,4-diones is described. The 1H-quinazoline-2,4dione 10 was made starting with fluorobenzoic acid in three high yielding steps. The key step of this synthesis involved the generation of the dianion of urea 7 and the subsequent intramolecular nucl