Synthesis of 1-(2-Carboxyethyl)-(1H,3H)-quinazoline-2,4-dione Derivatives. -Various quinazolinedione derivatives are prepared as possible new biologically active compounds starting from propionic acid derivative ( I).
Synthesis of derivatives of 1-(2-carboxyethyl)-(1H,3H)-quinazoline-2,4-dione
✍ Scribed by V. Mitskyavichyus
- Publisher
- Springer US
- Year
- 1997
- Tongue
- English
- Weight
- 175 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0009-3122
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A new synthesis of a series of 3-amino-1H-quinazoline-2,4-diones is described. The 1H-quinazoline-2,4dione 10 was made starting with fluorobenzoic acid in three high yielding steps. The key step of this synthesis involved the generation of the dianion of urea 7 and the subsequent intramolecular nucl
## Abstract We report an analysis of the europium‐shifted n.m.r. spectrum of 3‐(2′,4′‐dimethylphenyl)‐1__H__,3__H__‐quinazoline‐2,4‐dione and the resonance assignment of most of its protons.
## Abstract magnified image Quinazoline‐2,4(1__H__,3__H__)‐dione (1) reacts with α,ω‐dihaloalkanes to generate three types of quinazolinophanes. When the number of carbon atoms in the dihaloalkanes is **9**, a mixture of all the three types of quinazolinophanes (**2**), (**3**) and (**4**) was pro