We have developed a new methodology for the construction of 5-substituted pyrrolo [2,3-d]pyrimidines that involves the reduction of a nitroalkane to an oxime using the reducing ability of the Sn(SR 3 ) -species, followed by mild, acid-catalysed deoximation of the resulting adduct using Dowex-H + res
β¦ LIBER β¦
A New and Efficient Synthesis of Pyrrolo[2,3- d ]pyrimidine Anticancer Agents: Alimta (LY231514, MTA), Homo-Alimta, TNP-351, and Some Aryl 5-Substituted Pyrrolo[2,3- d ]pyrimidines
β Scribed by Taylor, Edward C.; Liu, Bin
- Book ID
- 120416736
- Publisher
- American Chemical Society
- Year
- 2003
- Tongue
- English
- Weight
- 204 KB
- Volume
- 68
- Category
- Article
- ISSN
- 0022-3263
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
A new and versatile synthesis of 5-subst
β
Dolorès Edmont; David M Williams
π
Article
π
2000
π
Elsevier Science
π
French
β 80 KB
A New Route to 7-Substituted Derivatives
β
Taylor, Edward C.; Liu, Bin
π
Article
π
2001
π
American Chemical Society
π
English
β 160 KB
ChemInform Abstract: A New Route to 7-Su
β
Edward C. Taylor; Bin Liu
π
Article
π
2010
π
John Wiley and Sons
β 31 KB
π 1 views
Exploitation of a new route to fused pyr
β
Edward C. Taylor; Bin Liu
π
Article
π
1999
π
Elsevier Science
π
French
β 185 KB
We have developed a new methodology for the construction of pyrrolo[2,3-~pyrimidines that involves Michael addition of 2,6-diamino-4(3H)-pyrimidinone or 2,4,6triaminopyrimidines to nitroolefins, followed by a Nef reaction of the resulting adduct to form an intermediate aldehyde that spontaneously cy
ChemInform Abstract: A New and Versatile
β
Dolores Edmont; David M. Williams
π
Article
π
2001
π
John Wiley and Sons
β 34 KB
π 2 views
ChemInform Abstract: A Short and Efficie
β
N. M. Sekhar; Palle V. R. Acharyulu; Yerramilli Anjaneyulu
π
Article
π
2011
π
John Wiley and Sons
β 30 KB
π 1 views