𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A New and Convergent Synthesis of (2 S )-7-(4,4‘-Bipiperidinylcarbonyl)-2,3,4,5- tetrahydro-4-methyl-3-oxo-1 H -1,4-benzodiazepine-2-acetic Acid Using a Palladium-Catalysed Aminocarbonylation Reaction

✍ Scribed by Etridge, Stephen K.; Hayes, Jerome F.; Walsgrove, Timothy C.; Wells, Andrew S.

Book ID
120199228
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
77 KB
Volume
3
Category
Article
ISSN
1083-6160

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

An alternate enantiospecific synthesis o
An alternate enantiospecific synthesis of methyl (S)-7-tert-butoxycarbonyl-2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetate
✍ Thomas W. Ku; Fadia E. Ali; William E. Bondinell; Karl F. Erhard; William F. Huf 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 220 KB

An alternate enantiospecific synthesis of methyl (S)-7-tert-butoxycarbonyl-2,3,4,5-tetrahydro-4-methyl-3-oxo-lH-l,4benzodiazepine-2-acetate ( ) is reported. The key step, which involves an intermolecular displacement of the activated aryl fluoride (9) by L-aspartic acid [~-methyl ester, proceeds wit

A new and efficient palladium-catalyzed
A new and efficient palladium-catalyzed synthesis of a 2,3,4,5-tetrahydro-1H-2,4-benzodiazepine-1,3-dione derivative
✍ Gabriele Bocelli; Marta Catellani; Federica Cugini; Raffaella Ferraccioli 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 121 KB

Tic palladium-catalyzed intramolecular cyclization of l-butyl-l(o-iodobenzyl)-3-pheaylurea 1 at gO°C m the Ixesence of carbon monoxide at atmospheric pressure gives the corresl~nding 2,3,4,5-teWahydro-IH-2,4benzodiazepine-1,3-dione derivative 2 in 91% yield. Yield and selectivity are strongly affect