A new 1,3-dipolar cycloaddition reaction : Synthesis of some isoxazolidine derivatives
β Scribed by M. Ochiai; M. Obayashi; K. Morita
- Publisher
- Elsevier Science
- Year
- 1967
- Tongue
- French
- Weight
- 459 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0040-4020
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π SIMILAR VOLUMES
## Abstract Several bisphosphonate esters (III) bearing a substituted isoxazolidine moiety are synthesized in the absence of any solvent in good yields and short reaction times.
## Abstract magnified image Asymmetric 1,3βdipolar cycloadditions of chiral nitrones to 1βpropeneβ1,3βsultone (**1**) were investigated. Chiral nitrones **6aβe** reacted with sultone **1** in toluene at 90 Β°C for 24β36 h to give the corresponding isoxazolidines in moderate yields with high regiose
## Abstract magnified image A simple diastereoselective route to nicotine derivatives is presented. The oneβpot three component 1,3βdipolar cycloaddition reaction of the KnΓΆevenagel adducts of a number of aromatic aldehydes and malononitrile with an azomethine ylide derived __in situ__ from pyridin