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Diastereoselective synthesis of nicotine derivatives via 1,3-dipolar cycloaddition reactions

✍ Scribed by Mehdi Ghandi; Abuzar Taheri; Alireza Abbasi

Publisher
Journal of Heterocyclic Chemistry
Year
2010
Tongue
English
Weight
339 KB
Volume
47
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

magnified image A simple diastereoselective route to nicotine derivatives is presented. The one‐pot three component 1,3‐dipolar cycloaddition reaction of the Knöevenagel adducts of a number of aromatic aldehydes and malononitrile with an azomethine ylide derived in situ from pyridine‐3‐carbaldehyde and sarcosine give access to nicotine derivatives in good yields. J. Heterocyclic Chem., (2010).

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