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A new 111in-bleomycin complex for combined radiotherapy and chemotherapy

✍ Scribed by De-Yan Hou; Hans Hoch; Gerald S. Johnston; K. C. Tsou; Alfred E. Jones; Raymond J. Farkas; Elizabeth E. Miller; Steven M. Larson


Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
651 KB
Volume
29
Category
Article
ISSN
0022-4790

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## Abstract A new ^111^In‐bleomycin complex (^111^In‐BLMC) is here reported. Its radiochemical purity was 99% by thin‐layer chromatography (TLC) (Rf 0.65) and in 5% agarose gel electrophoresis in 0.02 M NaHCO~3~ it migrated toward the anode. Autoradiographs of TLC and gel electrophoresis plates sho

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## Abstract We have found a new ^111^In‐bleomycin complex (BLMC), which has high affinity to tumor, does not bind to transferrin and is stable in vivo. Distribution in animals bearing glioma, hepatoma, or mammary adenocarcinoma at 48 hours showed: the ratios of tumor to blood, brain, heart, lung, l