The instrument D19 at the Institut Laue-Langevin, Grenoble, has been used to undertake neutron fibre diffraction studies of the location of water around the D form of the DNA double helix. These studies clearly show the distribution of water in the small and large grooves of the molecule and, togeth
A neutron diffraction study of the distribution of water in the A form of the DNA double helix
β Scribed by P. Langan; V.T. Forsyth; A. Mahendrasingam; D. Alexeev; W. Fuller; S.A. Mason
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 355 KB
- Volume
- 180-181
- Category
- Article
- ISSN
- 0921-4526
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β¦ Synopsis
High angle diffraction data from ordered fibres of DNA in the A form have been collected on diffractometer D19 at the Institute Laue-Langevin.
By exploiting the ability to isotopically replace H,O surrounding the DNA by D,O we have been able to locate water around the double helix.
π SIMILAR VOLUMES
## Abstract The interaction energy between water and the DNA single helix in the A conformation is computed at a number of planar cross sections perpendicular to the long axis of the helix and for cylindrical surfaces enclosing the helix. In addition, Monte Carlo simulations are presented for a sma