A network map of BDNF/TRKB and BDNF/p75NTR signaling system
β Scribed by Sandhya, Varot K.; Raju, Rajesh; Verma, Renu; Advani, Jayshree; Sharma, Rakesh; Radhakrishnan, Aneesha; Nanjappa, Vishalakshi; Narayana, Jayasuryan; Somani, B. L.; Mukherjee, Kanchan K.; Pandey, Akhilesh; Christopher, Rita; Prasad, T. S. Keshava
- Book ID
- 120490759
- Publisher
- Springer Netherlands
- Year
- 2013
- Tongue
- English
- Weight
- 428 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1873-9601
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The neurotrophin brain-derived neurotrophic factor (BDNF) binds to two cell surface receptors: TrkB receptors that promote neuronal survival and differentiation and p75NTR that induces apoptosis or survival. BDNF, as well as the other members of the neurotrophin family, is synthesized as a larger pr
## Abstract Brainβderived neurotrophic factor (BDNF) is critically involved in modeling the developing nervous system and is an important regulator of a variety of crucial functions in the mature CNS. BDNF exerts its action through interactions with two transmembrane receptors, either separately or