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Increased BDNF levels and association with the NTRK2 gene suggest a disruption of BDNF/TRKB signaling in autism

✍ Scribed by C. Correia; A.F. Sequeira; J. Almeida; L. Gallagher; G. Oliveira; A.M. Vicente

Book ID: 116552338
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 72 KB
Volume: 28
Category: Article
ISSN: 0736-5748
DOI: 10.1016/j.ijdevneu.2010.07.206

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## Abstract Several lines of evidence indicate an involvement of brain derived neurotrophic factor (BDNF) in body weight regulation and activity: heterozygous __Bdnf__ knockout mice (__Bdnf__^+/−^) are hyperphagic, obese, and hyperactive; furthermore, central infusion of BDNF leads to severe, dose‐