A Nanoparticulate Drug-Delivery System for Rivastigmine: Physico-Chemical and in vitro Biological Characterization

✍ Scribed by Emanuela Fabiola Craparo; Giovanna Pitarresi; Maria Luisa Bondì; Maria Pia Casaletto; Mariano Licciardi; Gaetano Giammona

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 297 KB
• Volume: 8
• Category: Article
• ISSN: 1616-5187
• DOI: 10.1002/mabi.200700165

✦ Synopsis

Abstract

The preparation and characterization of surface‐PEGylated polymeric nanoparticles are described. These systems were obtained by UV irradiation of PHM and PHM‐PEG~2000~ as an inverse microemulsion, using an aqueous solution of the PHM/PHM‐PEG~2000~ copolymer mixture as the internal phase and triacetin saturated with water as the external phase, and characterized by dimensional analysis, zeta‐potential measurements and XPS. in vitro biological tests demonstrated their cell compatibility and their ability to escape from phagocytosis. Rivastigmine was encapsulated into the nanoparticle structure and drug‐release profiles from loaded samples were investigated in PBS at pH = 7.4 and human plasma.

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