A mutant P53 can activate apoptosis through a mechanism distinct from those induced by wild type P53
β Scribed by Ming He; Paul S Rennie; Visia Dragowska; Colleen C Nelson; William Jia
- Book ID
- 117104118
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 261 KB
- Volume
- 517
- Category
- Article
- ISSN
- 0014-5793
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
p53 protein is a transcription factor involved in multiple tumor-suppressor activities including cell cycle control and apoptosis. TP53 gene is frequently mutated in glioblastoma, suggesting the importance of inactivation of this gene product in gliomagenesis. Restoration of p53 function in glioblas
The tumor suppressor p53 plays a central role in negative growth control, including growth arrest and apoptosis. Interferons (IFNs) are capable of modulating a variety of cellular responses, including apoptosis. In this study, we have evaluated the influence of y-and a-interferon (IFN) on wild-type