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Caffeine enhanced radiosensitivity of rat tumor cells with a mutant-type p53 by inducing apoptosis in a p53-independent manner

โœ Scribed by Keiko Higuchi; Norio Mitsuhashi; Jun-ichi Saitoh; Katsuya Maebayashi; Hideyuki Sakurai; Tetsuo Akimoto; Hideo Niibe


Book ID
117469802
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
567 KB
Volume
152
Category
Article
ISSN
0304-3835

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p53 protein is a transcription factor involved in multiple tumor-suppressor activities including cell cycle control and apoptosis. TP53 gene is frequently mutated in glioblastoma, suggesting the importance of inactivation of this gene product in gliomagenesis. Restoration of p53 function in glioblas