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A monoclonal antibody which interferes with the binding of type 1 plasminogen activator inhibitor (PAI-1) to its binding protein vitronectin (VN)

✍ Scribed by Seiffert, D.; Podor, T.J.; Mimuro, J.; Loskutoff, D.J.


Book ID
123528136
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
162 KB
Volume
3
Category
Article
ISSN
0268-9499

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✍ Gordon Royle; Gary Deng; Dietmar Seiffert; David J. Loskutoff πŸ“‚ Article πŸ“… 2001 πŸ› Elsevier Science 🌐 English βš– 272 KB

Plasminogen activator inhibitor type-1 (PAI-1) is bound to vitronectin (VN) in plasma and in the extracellular matrix. We previously employed a domainswapping approach to show that the high-affinity binding site for PAI-1 in VN is contained within residues 12-30 in the amino-terminal somatomedin B (