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A monoclonal antibody recognizing a polymorphic determinant on HLA-DR antigens except DR 7 and DRw9

✍ Scribed by K. Ogasawara; M. Kasahara; T. Nakayama; N. Ishikawa; H. Kunikane; S. Hawkin; H. Kojima; H. Ikeda; A. Wakisaka; Y. Kikuchi; M. Aizawa


Book ID
115093748
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
226 KB
Volume
26
Category
Article
ISSN
0001-2815

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We describe here two monoclonal antibodies with HLA-DR7 serologic specificity. The antibodies, S FR 16-DR7M, a cytotoxic rat IgM antibody of high affinity, and SFR16-DR7G, a noncytotoxic antibody of the rat IgG 2a class, react with only DR7-positive cells in radioimmunoassay. The cytotoxic activity