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A molecular model for interfacial activation in phospholipase A2

โœ Scribed by J. Warwicker


Book ID
117107265
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
670 KB
Volume
404
Category
Article
ISSN
0014-5793

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The X-ray structures of pancreatic bovine and porcine phospholipases A2 have been used along with interactive computer graphics to design conformationally rigid, novel compounds (1-meta-hydroxybenzyl-2-substituted acenaphthenes) directed at the active sites of these enzymes. In vitro testing confirm