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A model for the molecular mechanism of interfacial activation of phospholipase A2 supporting the substrate theory

✍ Scribed by Tom Thuren


Book ID
115920922
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
343 KB
Volume
229
Category
Article
ISSN
0014-5793

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Molecular modeling in the design of phos
✍ William C. Ripka; William J. Sipio; William G. Galbraith πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 English βš– 393 KB

The X-ray structures of pancreatic bovine and porcine phospholipases A2 have been used along with interactive computer graphics to design conformationally rigid, novel compounds (1-meta-hydroxybenzyl-2-substituted acenaphthenes) directed at the active sites of these enzymes. In vitro testing confirm