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A molecular hypothesis concerning the pathogenesis of myasthenia gravis

✍ Scribed by Norstrand, Iris Fletcher


Book ID
122090512
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
386 KB
Volume
16
Category
Article
ISSN
0306-9877

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Myasthenia gravis (MG) and its animal model experimental autoimmune myasthenia gravis (EAMG) are caused by autoantibodies against nicotinic acetylcholine receptor (AChR) in skeletal muscle. The production of anti-AChR antibodies is mediated by cytokines produced by CD4+ and CD8+ T helper (Th) cells.