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A Molecular Dynamics Study of Ras Clustering in Membrane Domains

✍ Scribed by Li, Hualin; Li, Zhenlong; Gorfe, Alemayehu

Book ID
122169574
Publisher
Biophysical Society
Year
2012
Tongue
English
Weight
40 KB
Volume
102
Category
Article
ISSN
0006-3495

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Recognition of Ras by its downstream target Raf is mediated by a Rasrecognition region in the Ras-binding domain (RBD) of Raf. Residues 78-89 in this region occupy two different conformations in the ensemble of NMR solution structures of the RBD: a fully ␣-helical one, and one where 87-90 form a typ